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Without writing a book and explaining every single trial in detail, I’ll share the key takeaway points: Trials #1-4 demonstrated an excellent safety profile in which AOD-9604 was well-tolerated and safe, with next to no difference compared to a placebo Trial #5 saw patients taking the AOD-9604 peptide lose 2.8 kg on a dose of 1 mg, compared to the placebo group losing 0.8 kg over the same time period
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184,200,220,221 Finally, the hydrophobic and dispersion interactions between β-sheets are overcome, as the β-crystallites collapse in a stick–slip motion, giving rise to a short strain-softening period immediately prior to failure when the fiber ruptures